TY - JOUR T1 - Glycinergic Projection Neurons of the Cerebellum JF - The Journal of Neuroscience JO - J. Neurosci. SP - 10104 LP - 10110 DO - 10.1523/JNEUROSCI.2087-09.2009 VL - 29 IS - 32 AU - Martha W. Bagnall AU - Brian Zingg AU - Alexandra Sakatos AU - Setareh H. Moghadam AU - Hanns Ulrich Zeilhofer AU - Sascha du Lac Y1 - 2009/08/12 UR - http://www.jneurosci.org/content/29/32/10104.abstract N2 - The cerebellum funnels its entire output through a small number of presumed glutamatergic premotor projection neurons in the deep cerebellar nuclei and GABAergic neurons that feed back to the inferior olive. Here we use transgenic mice selectively expressing green fluorescent protein in glycinergic neurons to demonstrate that many premotor output neurons in the medial cerebellar (fastigial) nuclei are in fact glycinergic, not glutamatergic as previously thought. These neurons exhibit similar firing properties as neighboring glutamatergic neurons and receive direct input from both Purkinje cells and excitatory fibers. Glycinergic fastigial neurons make functional projections to vestibular and reticular neurons in the ipsilateral brainstem, whereas their glutamatergic counterparts project contralaterally. Together, these data suggest that the cerebellum can influence motor outputs via two distinct and complementary pathways. ER -