TY - JOUR T1 - Genetic Deletion of A<sub>2A</sub> Adenosine Receptors in the Striatum Selectively Impairs Habit Formation JF - The Journal of Neuroscience JO - J. Neurosci. SP - 15100 LP - 15103 DO - 10.1523/JNEUROSCI.4215-09.2009 VL - 29 IS - 48 AU - Chunxiu Yu AU - Jay Gupta AU - Jiang-Fan Chen AU - Henry H. Yin Y1 - 2009/12/02 UR - http://www.jneurosci.org/content/29/48/15100.abstract N2 - A2A receptors are a major class of G-protein-coupled receptors for adenosine. Highly expressed in the striatum, on the projection neurons giving rise to the striatopallidal or “indirect” pathway, they have been implicated in sleep, addiction, and other processes, yet their role in the control of striatal circuits and behavior remains unclear. Using established assays from the instrumental learning paradigm, we showed that mice with striatum-specific deletion of A2A receptors were selectively impaired in habit formation. After training that generated habitual lever pressing in wild-type controls, the performance of striatum-specific A2A knock-out mice remained goal directed, being highly sensitive to outcome devaluation and reversal of the action–outcome contingency. These data demonstrate a critical role for A2A receptors on striatopallidal medium spiny projection neurons in shaping behavior and decision making, providing the first instance of a selective alteration in instrumental learning after striatum-specific genetic manipulations. ER -