RT Journal Article
SR Electronic
T1 Reelin Regulates Postnatal Neurogenesis and Enhances Spine Hypertrophy and Long-Term Potentiation
JF The Journal of Neuroscience
JO J. Neurosci.
FD Society for Neuroscience
SP 4636
OP 4649
DO 10.1523/JNEUROSCI.5284-09.2010
VO 30
IS 13
A1 Lluís Pujadas
A1 Agnès Gruart
A1 Carles Bosch
A1 Lídia Delgado
A1 Cátia M. Teixeira
A1 Daniela Rossi
A1 Luis de Lecea
A1 Albert Martínez
A1 José M. Delgado-García
A1 Eduardo Soriano
YR 2010
UL http://www.jneurosci.org/content/30/13/4636.abstract
AB Reelin, an extracellular protein essential for neural migration and lamination, is also expressed in the adult brain. To unravel the function of this protein in the adult forebrain, we generated transgenic mice that overexpress Reelin under the control of the CaMKIIα promoter. Overexpression of Reelin increased adult neurogenesis and impaired the migration and positioning of adult-generated neurons. In the hippocampus, the overexpression of Reelin resulted in an increase in synaptic contacts and hypertrophy of dendritic spines. Induction of long-term potentiation (LTP) in alert-behaving mice showed that Reelin overexpression evokes a dramatic increase in LTP responses. Hippocampal field EPSP during a classical conditioning paradigm was also increased in these mice. Our results indicate that Reelin levels in the adult brain regulate neurogenesis and migration, as well as the structural and functional properties of synapses. These observations suggest that Reelin controls developmental processes that remain active in the adult brain.