TY - JOUR T1 - Slow and Persistent Postinhibitory Rebound Acts as an Intrinsic Short-Term Memory Mechanism JF - The Journal of Neuroscience JO - J. Neurosci. SP - 4687 LP - 4692 DO - 10.1523/JNEUROSCI.2998-09.2010 VL - 30 IS - 13 AU - Jean-Marc Goaillard AU - Adam L. Taylor AU - Stefan R. Pulver AU - Eve Marder Y1 - 2010/03/31 UR - http://www.jneurosci.org/content/30/13/4687.abstract N2 - Many neurons exhibit postinhibitory rebound (PIR), in which neurons display enhanced excitability following inhibition. PIR can strongly influence the timing of spikes on rebound from an inhibitory input. We studied PIR in the lateral pyloric (LP) neuron of the stomatogastric ganglion of the crab Cancer borealis. The LP neuron is part of the pyloric network, a central pattern generator that normally oscillates with a period of ∼1 s. We used the dynamic clamp to create artificial rhythmic synaptic inputs of various periods and duty cycles in the LP neuron. Surprisingly, we found that the strength of PIR increased slowly over multiple cycles of synaptic input. Moreover, this increased excitability persisted for 10–20 s after the rhythmic inhibition was removed. These effects are considerably slower than the rhythmic activity typically observed in LP. Thus this slow postinhibitory rebound allows the neuron to adjust its level of excitability to the average level of inhibition over many cycles, and is another example of an intrinsic “short-term memory” mechanism. ER -