RT Journal Article
SR Electronic
T1 Excitatory Glycine Responses of CNS Myelin Mediated by NR1/NR3 “NMDA” Receptor Subunits
JF The Journal of Neuroscience
JO J. Neurosci.
FD Society for Neuroscience
SP 11501
OP 11505
DO 10.1523/JNEUROSCI.1593-10.2010
VO 30
IS 34
A1 Juan C. Piña-Crespo
A1 Maria Talantova
A1 Ileana Micu
A1 Bradley States
A1 H.-S. Vincent Chen
A1 Shichun Tu
A1 Nobuki Nakanishi
A1 Gary Tong
A1 Dongxian Zhang
A1 Stephen F. Heinemann
A1 Gerald W. Zamponi
A1 Peter K. Stys
A1 Stuart A. Lipton
YR 2010
UL http://www.jneurosci.org/content/30/34/11501.abstract
AB NMDA receptors are typically excited by a combination of glutamate and glycine. Here we describe excitatory responses in CNS myelin that are gated by a glycine agonist alone and mediated by NR1/NR3 “NMDA” receptor subunits. Response properties include activation by d-serine, inhibition by the glycine-site antagonist CNQX, and insensitivity to the glutamate-site antagonist d-APV. d-Serine responses were abrogated in NR3A-deficient mice. Our results suggest the presence of functional NR1/NR3 receptors in CNS myelin.