PT - JOURNAL ARTICLE AU - Paul C. Fletcher AU - Antonella Napolitano AU - Andrew Skeggs AU - Sam R. Miller AU - Bruno Delafont AU - Victoria C. Cambridge AU - Sanne de Wit AU - Pradeep J. Nathan AU - Allison Brooke AU - Stephen O'Rahilly AU - I. Sadaf Farooqi AU - Edward T. Bullmore TI - Distinct Modulatory Effects of Satiety and Sibutramine on Brain Responses to Food Images in Humans: A Double Dissociation across Hypothalamus, Amygdala, and Ventral Striatum AID - 10.1523/JNEUROSCI.3323-10.2010 DP - 2010 Oct 27 TA - The Journal of Neuroscience PG - 14346--14355 VI - 30 IP - 43 4099 - http://www.jneurosci.org/content/30/43/14346.short 4100 - http://www.jneurosci.org/content/30/43/14346.full SO - J. Neurosci.2010 Oct 27; 30 AB - We used functional magnetic resonance imaging to explore brain responses to food images in overweight humans, examining independently the impact of a prescan meal (“satiety”) and the anti-obesity drug sibutramine, a serotonin and noradrenaline reuptake inhibitor. We identified significantly different responses to these manipulations in amygdala, hypothalamus, and ventral striatum. Each region was specifically responsive to high-calorie compared to low-calorie food images. However, the ventral striatal response was attenuated by satiety (but unaffected by sibutramine), while the hypothalamic and amygdala responses were attenuated by drug but unaffected by satiety. Direct assessment of regional interactions confirmed the significance of this double dissociation. We explored the regional responses in greater detail by determining whether they were predictive of eating behavior and weight change. We observed that across the different regions, the individual-specific magnitude of drug- and satiety-induced modulation was associated with both variables: the sibutramine-induced modulation of the hypothalamic response was correlated with the drug's impact on both weight and subsequently measured ad libitum eating. The satiety-induced modulation of striatal response also correlated with subsequent ad libitum eating. These results suggest that hypothalamus and amygdala have roles in the control of food intake that are distinct from those of ventral striatum. Furthermore, they support a regionally specific effect on brain function through which sibutramine exerts its clinical effect.