PT  - JOURNAL ARTICLE
AU  - L Skirboll
AU  - T Hokfelt
AU  - G Dockray
AU  - J Rehfeld
AU  - M Brownstein
AU  - AC Cuello
TI  - Evidence for periaqueductal cholecystokinin-substance P neurons projecting to the spinal cord
AID  - 10.1523/JNEUROSCI.03-06-01151.1983
DP  - 1983 Jun 01
TA  - The Journal of Neuroscience
PG  - 1151--1157
VI  - 3
IP  - 6
4099  - http://www.jneurosci.org/content/3/6/1151.short
4100  - http://www.jneurosci.org/content/3/6/1151.full
SO  - J. Neurosci.1983 Jun 01; 3
AB  - Using indirect immunofluorescence techniques combined with retrogradely transported fluorescent dyes, cholecystokinin (CCK)-like and substance P immunoreactive cell bodies in the periaqueductal central grey of the rat brain were studied. Data from both adjacent sections and elution- restaining techniques indicated that some of these central grey cells contain both a CCK-like peptide and substance P. Injection of the fluorescent dye, Fast Blue, into the cervical spinal cord indicated that this CCK-substance P cell group is a descending system. These findings provide evidence for two peptides in a single neuron, and the possible functional significance of such an occurrence is discussed.