TY - JOUR T1 - Cholecystokinin potentiates dopamine-mediated behaviors: evidence for modulation specific to a site of coexistence JF - The Journal of Neuroscience JO - J. Neurosci. SP - 1972 LP - 1983 DO - 10.1523/JNEUROSCI.05-08-01972.1985 VL - 5 IS - 8 AU - JN Crawley AU - JA Stivers AU - LK Blumstein AU - SM Paul Y1 - 1985/08/01 UR - http://www.jneurosci.org/content/5/8/1972.abstract N2 - Cholecystokinin coexists with dopamine in mesolimbic neurons in mammalian brain. When injected directly into the nucleus accumbens, cholecystokinin (CCK) potentiated dopamine (DA)-induced hyperlocomotion and apomorphine-induced stereotypy. These effects were not mimicked by nonsulfated CCK, but were blocked by proglumide, a putative CCK antagonist, as well as by antisera raised against sulfated CCK. CCK alone had no effect on locomotion or sterotypy, indicating that this peptide acts primarily as a modulator of DA-mediated behaviors in the mesolimbic pathway. In addition, CCK did not potentiate DA-induced hyperlocomotion or apomorphine-induced stereotypy when injected into the caudate nucleus, where CCK and DA are localized in separate neurons in rats. Facilitation of DA-mediated behaviors by CCK may represent a functional interaction specific to the neuromodulator-neurotransmitter coexistence phenomenon. ER -