TY - JOUR T1 - Guidance of neuronal growth cones in the grasshopper embryo. II. Recognition of a specific axonal pathway by the aCC neuron JF - The Journal of Neuroscience JO - J. Neurosci. SP - 3532 LP - 3541 DO - 10.1523/JNEUROSCI.06-12-03532.1986 VL - 6 IS - 12 AU - S du Lac AU - MJ Bastiani AU - CS Goodman Y1 - 1986/12/01 UR - http://www.jneurosci.org/content/6/12/3532.abstract N2 - In the previous paper, we experimentally analyzed the selective affinity of the pCC growth cone for the MP1/dMP2 fascicle in the grasshopper embryo. Here we describe a similar experimental analysis demonstrating the selective affinity of the aCC growth cone for the U fascicle. These results support the labeled-pathways hypothesis. The 2 sets of cell ablation experiments argue against the simple location of axons, the simple timing of axon outgrowth, and/or simple quantitative differences in the expression of a common surface label being the major determinant in pathway selection by neuronal growth cones. Rather, these 2 examples of growth-cone specificity, together with previous studies on the G growth cone, suggest that neuronal recognition molecules are differentially expressed on the surfaces of different embryonic axonal pathways and tracts and are used to guide growth cones through a series of choice points to their targets. ER -