RT Journal Article
SR Electronic
T1 Gradient of extrajunctional acetylcholine receptors early after denervation of mammalian muscle
JF The Journal of Neuroscience
JO J. Neurosci.
FD Society for Neuroscience
SP 1606
OP 1612
DO 10.1523/JNEUROSCI.06-06-01606.1986
VO 6
IS 6
A1 TA Levitt-Gilmour
A1 MM Salpeter
YR 1986
UL http://www.jneurosci.org/content/6/6/1606.abstract
AB After denervation, the number of acetylcholine receptors (AChR) found within the endplate band of skeletal muscle increases transiently by about twofold. In this study, we used EM autoradiography to show that this increased endplate band label is not due to an elevated site density of receptors at the junctional folds. Rather, AChR site density within 500 microns of the endplate was found to be 4 X higher than in non-endplate areas defined as greater than 2 mm from the endplate. This nonuniform distribution of extrajunctional AChR early after denervation could represent a transient gradient,similar to that reported shortly after innervation during development.