RT Journal Article
SR Electronic
T1 The effect of periarcuate lesions in the monkey on the performance of symmetrically and asymmetrically reinforced visual and auditory go, no- go tasks
JF The Journal of Neuroscience
JO J. Neurosci.
FD Society for Neuroscience
SP 2054
OP 2063
DO 10.1523/JNEUROSCI.06-07-02054.1986
VO 6
IS 7
A1 M Petrides
YR 1986
UL http://www.jneurosci.org/content/6/7/2054.abstract
AB Monkeys with lesions restricted to the periarcuate region of the frontal cortex were impaired on go, no-go tasks in which, depending on the stimulus present on any given trial, they were rewarded either for pushing a manipulandum or for withholding this response for a given period of time. By contrast, these animals were able to learn at a normal rate go, no-go tasks in which they were rewarded if they responded in the presence of a “positive” stimulus, but not in the presence of a “negative” stimulus. In the latter situation, responding in the presence of the “negative” stimulus was extinguished through non- reward, whereas the tasks on which impairments were demonstrated required solution on the basis of a conditional rule: If stimulus A, respond, and if stimulus B, withhold responding, to receive reward. Because the 2 experimental situations were identical in every respect except for the one critical difference in the testing procedure, the present set of experiments provides a powerful demonstration of the involvement of the periarcuate cortex in conditional learning with exteroceptive stimuli.