RT Journal Article
SR Electronic
T1 A selective mnemonic role for the hippocampus in monkeys: memory for the location of objects
JF The Journal of Neuroscience
JO J. Neurosci.
FD Society for Neuroscience
SP 4159
OP 4167
DO 10.1523/JNEUROSCI.08-11-04159.1988
VO 8
IS 11
A1 JK Parkinson
A1 EA Murray
A1 M Mishkin
YR 1988
UL http://www.jneurosci.org/content/8/11/4159.abstract
AB Monkeys were trained preoperatively on a one-trial learning task in which they were required to associate in memory a novel object and the place in which it had just appeared. After learning the task to a level of 80% correct responses, they received bilateral ablations of either the hippocampal formation or the amygdaloid complex. The monkeys with amygdalectomy showed a small drop in performance initially but then regained their preoperative level. By contrast, the monkeys with hippocampectomy dropped to near-chance levels of performance and remained there throughout postoperative testing. Both groups performed at better than 90% correct responses on a test of recognition memory. These results, taken together with earlier work, suggest that although the hippocampus and amygdala appear to participate equally in object recognition, only the hippocampus is critical for the rapid formation of object-place associations.