PT  - JOURNAL ARTICLE
AU  - Masato Sawada
AU  - Naoko Kaneko
AU  - Hiroyuki Inada
AU  - Hiroaki Wake
AU  - Yasuko Kato
AU  - Yuchio Yanagawa
AU  - Kazuto Kobayashi
AU  - Tomomi Nemoto
AU  - Junichi Nabekura
AU  - Kazunobu Sawamoto
TI  - Sensory Input Regulates Spatial and Subtype-Specific Patterns of Neuronal Turnover in the Adult Olfactory Bulb
AID  - 10.1523/JNEUROSCI.0614-11.2011
DP  - 2011 Aug 10
TA  - The Journal of Neuroscience
PG  - 11587--11596
VI  - 31
IP  - 32
4099  - http://www.jneurosci.org/content/31/32/11587.short
4100  - http://www.jneurosci.org/content/31/32/11587.full
SO  - J. Neurosci.2011 Aug 10; 31
AB  - Throughout life, new neurons are added and old ones eliminated in the adult mouse olfactory bulb. Previous studies suggested that olfactory experience controls the process by which new neurons are integrated into mature circuits. Here we report novel olfactory-experience-dependent mechanisms of neuronal turnover. Using two-photon laser-scanning microscopy and sensory manipulations in adult live mice, we found that the neuronal turnover was dynamically controlled by olfactory input in a neuronal subtype-specific manner. Olfactory input enhanced this turnover, which was characterized by the reiterated use of the same positions in the glomeruli by new neurons. Our results suggest that olfactory-experience-dependent modification of neuronal turnover confers structural plasticity and stability on the olfactory bulb.