TY - JOUR T1 - Dynamics of Population Response to Changes of Motion Direction in Primary Visual Cortex JF - The Journal of Neuroscience JO - J. Neurosci. SP - 12767 LP - 12777 DO - 10.1523/JNEUROSCI.4307-10.2011 VL - 31 IS - 36 AU - Wei Wu AU - Paul H. Tiesinga AU - Thomas R. Tucker AU - Stephen R. Mitroff AU - David Fitzpatrick Y1 - 2011/09/07 UR - http://www.jneurosci.org/content/31/36/12767.abstract N2 - The visual system is thought to represent the direction of moving objects in the relative activity of large populations of cortical neurons that are broadly tuned to the direction of stimulus motion, but how changes in the direction of a moving stimulus are represented in the population response remains poorly understood. Here we take advantage of the orderly mapping of direction selectivity in ferret primary visual cortex (V1) to explore how abrupt changes in the direction of a moving stimulus are encoded in population activity using voltage-sensitive dye imaging. For stimuli moving in a constant direction, the peak of the V1 population response accurately represented the direction of stimulus motion, but following abrupt changes in motion direction, the peak transiently departed from the direction of stimulus motion in a fashion that varied with the direction offset angle and was well predicted from the response to the component directions. We conclude that cortical dynamics and population coding mechanisms combine to place constraints on the accuracy with which abrupt changes in direction of motion can be represented by cortical circuits. ER -