PT  - JOURNAL ARTICLE
AU  - Ilya E. Monosov
AU  - David L. Sheinberg
AU  - Kirk G. Thompson
TI  - The Effects of Prefrontal Cortex Inactivation on Object Responses of Single Neurons in the Inferotemporal Cortex during Visual Search
AID  - 10.1523/JNEUROSCI.2995-11.2011
DP  - 2011 Nov 02
TA  - The Journal of Neuroscience
PG  - 15956--15961
VI  - 31
IP  - 44
4099  - http://www.jneurosci.org/content/31/44/15956.short
4100  - http://www.jneurosci.org/content/31/44/15956.full
SO  - J. Neurosci.2011 Nov 02; 31
AB  - Inferotemporal cortex (IT) is believed to be directly involved in object processing and necessary for accurate and efficient object recognition. The frontal eye field (FEF) is an area in the primate prefrontal cortex that is involved in visual spatial selection and is thought to guide spatial attention and eye movements. We show that object-selective responses of IT neurons and behavioral performance are affected by changes in frontal eye field activity. This was found in monkeys performing a search classification task by temporarily inactivating subregions of FEF while simultaneously recording the activity from single neurons in IT. The effect on object selectivity and performance was specific, occurring in a predictable spatially dependent manner and was strongest when the IT neuron's preferred target was presented in the presence of distractors. FEF inactivation did not affect IT responses on trials in which the nonpreferred target was presented in the search array.