PT  - JOURNAL ARTICLE
AU  - Nobuyoshi Suto
AU  - Roy A. Wise
TI  - Satiating Effects of Cocaine Are Controlled by Dopamine Actions in the Nucleus Accumbens Core
AID  - 10.1523/JNEUROSCI.1903-11.2011
DP  - 2011 Dec 07
TA  - The Journal of Neuroscience
PG  - 17917--17922
VI  - 31
IP  - 49
4099  - http://www.jneurosci.org/content/31/49/17917.short
4100  - http://www.jneurosci.org/content/31/49/17917.full
SO  - J. Neurosci.2011 Dec 07; 31
AB  - Intravenous cocaine intake in laboratory animals is characterized by periods of apparent drug satiety between regularly spaced earned injections. The reinforcing properties of cocaine are linked primarily to dopaminergic neurotransmission in the shell and not the core of nucleus accumbens. To determine whether the satiating effects of cocaine are similarly mediated, we perfused dopamine receptor agonists into the core or the shell during intravenous cocaine self-administrations by rats. Neither D1-type (SKF38393) nor D2-type (quinpirole) agonist was effective when given alone. However, a combination of the two agonists perfused into the core but not the shell significantly increased the time between cocaine self-injections, decreasing the amount of earned intake. Together with previous findings, the current data suggest that the satiating and reinforcing effects of cocaine are mediated by different ventral striatal output neurons.