PT  - JOURNAL ARTICLE
AU  - Roberto De Pasquale
AU  - S. Murray Sherman
TI  - Modulatory Effects of Metabotropic Glutamate Receptors on Local Cortical Circuits
AID  - 10.1523/JNEUROSCI.0090-12.2012
DP  - 2012 May 23
TA  - The Journal of Neuroscience
PG  - 7364--7372
VI  - 32
IP  - 21
4099  - http://www.jneurosci.org/content/32/21/7364.short
4100  - http://www.jneurosci.org/content/32/21/7364.full
SO  - J. Neurosci.2012 May 23; 32
AB  - Glutamatergic pathways in various thalamic and cortical circuits have been classified into two types: Class 1 and Class 2, where it has been suggested that Class 1 carries the main information for processing, and Class 2 is mainly modulatory. We now extend this to the local circuitry of visual cortex of the mouse by demonstrating the modulatory actions on the Class 1 pathway from layer 4 to layers 2/3 of a Class 2 input from adjacent locations in layers 2/3. We found that this Class 2 input produces a long-lasting hyperpolarization and suppresses the initial responses of input from layer 4 and that this involves the postsynaptic activation of Group II metabotropic glutamate receptors. This modulation also shifts the paired pulse ratio of the layer 4 input from depression to facilitation.