RT Journal Article
SR Electronic
T1 Olfactory Deficits Cause Anxiety-Like Behaviors in Mice
JF The Journal of Neuroscience
JO J. Neurosci.
FD Society for Neuroscience
SP 6718
OP 6725
DO 10.1523/JNEUROSCI.4287-11.2012
VO 32
IS 19
A1 Meredith E. Glinka
A1 Benjamin A. Samuels
A1 Assunta Diodato
A1 Jérémie Teillon
A1 Dan Feng Mei
A1 Benjamin M. Shykind
A1 René Hen
A1 Alexander Fleischmann
YR 2012
UL http://www.jneurosci.org/content/32/19/6718.abstract
AB Anxiety disorders are characterized by persistent fear in the absence of immediate threat and represent the most common psychiatric diseases, with an estimated 28% lifetime prevalence worldwide (Kessler et al., 2010). While symptoms of anxiety are typically evoked by sensory stimuli, it is unknown whether sensory deficits contribute to the development of anxiety disorders. Here we examine the effect of defined genetic mutations that compromise the function of the olfactory system on the development of anxiety-like behaviors in mice. We show that the functional inactivation of the main olfactory epithelium, but not the vomeronasal organ, causes elevated levels of anxiety. Anxiety-like behaviors are also observed in mice with a monoclonal nose, that are able to detect and discriminate odors but in which the patterns of odor-evoked neural activity are perturbed. In these mice, plasma corticosterone levels are elevated, suggesting that olfactory deficits can lead to chronic stress. These results demonstrate a central role for olfactory sensory cues in modulating anxiety in mice.