TY - JOUR T1 - How Do Short-Term Changes at Synapses Fine-Tune Information Processing? JF - The Journal of Neuroscience JO - J. Neurosci. SP - 14058 LP - 14063 DO - 10.1523/JNEUROSCI.3348-12.2012 VL - 32 IS - 41 AU - Achim Klug AU - J. Gerard G. Borst AU - Bruce A. Carlson AU - Cornelia Kopp-Scheinpflug AU - Vitaly A. Klyachko AU - Matthew A. Xu-Friedman Y1 - 2012/10/10 UR - http://www.jneurosci.org/content/32/41/14058.abstract N2 - Synaptic transmission is highly dependent on recent activity and can lead to depression or facilitation of synaptic strength. This phenomenon is called “short-term synaptic plasticity” and is shown at all synapses. While much work has been done to understand the mechanisms of short-term changes in the state of synapses, short-term plasticity is often thought of as a mechanistic consequence of the design of a synapse. This review will attempt to go beyond this view and discuss how, on one hand, complex neuronal activity affects the short-term state of synapses, but also how these dynamic changes in synaptic strength affect information processing in return. ER -