RT Journal Article
SR Electronic
T1 High-Frequency Hippocampal Oscillations Activated by Optogenetic Stimulation of Transplanted Human ESC-Derived Neurons
JF The Journal of Neuroscience
JO J. Neurosci.
FD Society for Neuroscience
SP 15837
OP 15842
DO 10.1523/JNEUROSCI.3735-12.2012
VO 32
IS 45
A1 Juan C. Piña-Crespo
A1 Maria Talantova
A1 Eun-Gyung Cho
A1 Walid Soussou
A1 Nima Dolatabadi
A1 Scott D. Ryan
A1 Rajesh Ambasudhan
A1 Scott McKercher
A1 Karl Deisseroth
A1 Stuart A. Lipton
YR 2012
UL http://www.jneurosci.org/content/32/45/15837.abstract
AB After transplantation, individual stem cell-derived neurons can functionally integrate into the host CNS; however, evidence that neurons derived from transplanted human embryonic stem cells (hESCs) can drive endogenous neuronal network activity in CNS tissue is still lacking. Here, using multielectrode array recordings, we report activation of high-frequency oscillations in the β and γ ranges (10–100 Hz) in the host hippocampal network via targeted optogenetic stimulation of transplanted hESC-derived neurons.