RT Journal Article SR Electronic T1 GluN2D Subunit-Containing NMDA Receptors Control Tissue Plasminogen Activator-Mediated Spatial Memory JF The Journal of Neuroscience JO J. Neurosci. FD Society for Neuroscience SP 12726 OP 12734 DO 10.1523/JNEUROSCI.6202-11.2012 VO 32 IS 37 A1 Pauline Obiang A1 Richard Macrez A1 Amandine Jullienne A1 Thomas Bertrand A1 Flavie Lesept A1 Carine Ali A1 Eric Maubert A1 Denis Vivien A1 VĂ©ronique Agin YR 2012 UL http://www.jneurosci.org/content/32/37/12726.abstract AB Tissue plasminogen activator (tPA) is a serine protease with pleiotropic actions in the CNS, such as synaptic plasticity and neuronal death. Some effects of tPA require its interaction with the GluN1 subunit of the NMDA receptor (NMDAR), leading to a potentiation of NMDAR signaling. We have reported previously that the pro-neurotoxic effect of tPA is mediated through GluN2D subunit-containing NMDARs. Thus, the aim of the present study was to determine whether GluN2D subunit-containing NMDARs drive tPA-mediated cognitive functions. To address this issue, a strategy of immunization designed to prevent the in vivo interaction of tPA with NMDARs and GluN2D-deficient mice were used in a set of behavioral tasks. Altogether, our data provide the first evidence that tPA influences spatial memory through its preferential interaction with GluN2D subunit-containing NMDARs.