PT - JOURNAL ARTICLE AU - Kelly Shen AU - Gleb Bezgin AU - R. Matthew Hutchison AU - Joseph S. Gati AU - Ravi S. Menon AU - Stefan Everling AU - Anthony R. McIntosh TI - Information Processing Architecture of Functionally Defined Clusters in the Macaque Cortex AID - 10.1523/JNEUROSCI.2709-12.2012 DP - 2012 Nov 28 TA - The Journal of Neuroscience PG - 17465--17476 VI - 32 IP - 48 4099 - http://www.jneurosci.org/content/32/48/17465.short 4100 - http://www.jneurosci.org/content/32/48/17465.full SO - J. Neurosci.2012 Nov 28; 32 AB - Computational and empirical neuroimaging studies have suggested that the anatomical connections between brain regions primarily constrain their functional interactions. Given that the large-scale organization of functional networks is determined by the temporal relationships between brain regions, the structural limitations may extend to the global characteristics of functional networks. Here, we explored the extent to which the functional network community structure is determined by the underlying anatomical architecture. We directly compared macaque (Macaca fascicularis) functional connectivity (FC) assessed using spontaneous blood oxygen level-dependent functional magnetic resonance imaging (BOLD-fMRI) to directed anatomical connectivity derived from macaque axonal tract tracing studies. Consistent with previous reports, FC increased with increasing strength of anatomical connection, and FC was also present between regions that had no direct anatomical connection. We observed moderate similarity between the FC of each region and its anatomical connectivity. Notably, anatomical connectivity patterns, as described by structural motifs, were different within and across functional modules: partitioning of the functional network was supported by dense bidirectional anatomical connections within clusters and unidirectional connections between clusters. Together, our data directly demonstrate that the FC patterns observed in resting-state BOLD-fMRI are dictated by the underlying neuroanatomical architecture. Importantly, we show how this architecture contributes to the global organizational principles of both functional specialization and integration.