TY - JOUR T1 - <em>In Vivo</em> Functional and Myeloarchitectonic Mapping of Human Primary Auditory Areas JF - The Journal of Neuroscience JO - J. Neurosci. SP - 16095 LP - 16105 DO - 10.1523/JNEUROSCI.1712-12.2012 VL - 32 IS - 46 AU - Frederic Dick AU - Adam Taylor Tierney AU - Antoine Lutti AU - Oliver Josephs AU - Martin I. Sereno AU - Nikolaus Weiskopf Y1 - 2012/11/14 UR - http://www.jneurosci.org/content/32/46/16095.abstract N2 - In contrast to vision, where retinotopic mapping alone can define areal borders, primary auditory areas such as A1 are best delineated by combining in vivo tonotopic mapping with postmortem cyto- or myeloarchitectonics from the same individual. We combined high-resolution (800 μm) quantitative T1 mapping with phase-encoded tonotopic methods to map primary auditory areas (A1 and R) within the “auditory core” of human volunteers. We first quantitatively characterize the highly myelinated auditory core in terms of shape, area, cortical depth profile, and position, with our data showing considerable correspondence to postmortem myeloarchitectonic studies, both in cross-participant averages and in individuals. The core region contains two “mirror-image” tonotopic maps oriented along the same axis as observed in macaque and owl monkey. We suggest that these two maps within the core are the human analogs of primate auditory areas A1 and R. The core occupies a much smaller portion of tonotopically organized cortex on the superior temporal plane and gyrus than is generally supposed. The multimodal approach to defining the auditory core will facilitate investigations of structure–function relationships, comparative neuroanatomical studies, and promises new biomarkers for diagnosis and clinical studies. ER -