@article {K{\"o}ver3699, author = {Hania K{\"o}ver and Kirt Gill and Yi-Ting L. Tseng and Shaowen Bao}, title = {Perceptual and Neuronal Boundary Learned from Higher-Order Stimulus Probabilities}, volume = {33}, number = {8}, pages = {3699--3705}, year = {2013}, doi = {10.1523/JNEUROSCI.3166-12.2013}, publisher = {Society for Neuroscience}, abstract = {During an early epoch of development, the brain is highly adaptive to the stimulus environment. Exposing young animals to a particular tone, for example, leads to an enlarged representation of that tone in primary auditory cortex. While the neural effects of simple tonal environments are well characterized, the principles that guide plasticity in more complex acoustic environments remain unclear. In addition, very little is known about the perceptual consequences of early experience-induced plasticity. To address these questions, we reared juvenile rats in complex multitone environments that differed in terms of the higher-order conditional probabilities between sounds. We found that the development of primary cortical acoustic representations, as well as frequency discrimination ability in adult animals, were shaped by the higher-order stimulus statistics of the early acoustic environment. Our results suggest that early experience-dependent cortical reorganization may mediate perceptual changes through statistical learning of the sensory input.}, issn = {0270-6474}, URL = {https://www.jneurosci.org/content/33/8/3699}, eprint = {https://www.jneurosci.org/content/33/8/3699.full.pdf}, journal = {Journal of Neuroscience} }