PT  - JOURNAL ARTICLE
AU  - Marieke R. Gilmartin
AU  - Hiroyuki Miyawaki
AU  - Fred J. Helmstetter
AU  - Kamran Diba
TI  - Prefrontal Activity Links Nonoverlapping Events in Memory
AID  - 10.1523/JNEUROSCI.0144-13.2013
DP  - 2013 Jun 26
TA  - The Journal of Neuroscience
PG  - 10910--10914
VI  - 33
IP  - 26
4099  - http://www.jneurosci.org/content/33/26/10910.short
4100  - http://www.jneurosci.org/content/33/26/10910.full
SO  - J. Neurosci.2013 Jun 26; 33
AB  - The medial prefrontal cortex (mPFC) plays an important role in memory. By maintaining a working memory buffer, neurons in prelimbic (PL) mPFC may selectively contribute to learning associations between stimuli that are separated in time, as in trace fear conditioning (TFC). Until now, evidence for this bridging role was largely descriptive. Here we used optogenetics to silence neurons in the PL mPFC of rats during learning in TFC. Memory formation was prevented when mPFC was silenced specifically during the interval separating the cue and shock. Our results provide support for a working memory function for these cells and indicate that associating two noncontiguous stimuli requires bridging activity in PL mPFC.