PT  - JOURNAL ARTICLE
AU  - Zhiyuan Zhu
AU  - Jianming Yan
AU  - Wei Jiang
AU  - Xin-gang Yao
AU  - Jing Chen
AU  - Lili Chen
AU  - Chenjing Li
AU  - Lihong Hu
AU  - Hualiang Jiang
AU  - Xu Shen
TI  - Arctigenin Effectively Ameliorates Memory Impairment in Alzheimer's Disease Model Mice Targeting Both β-Amyloid Production and Clearance
AID  - 10.1523/JNEUROSCI.4790-12.2013
DP  - 2013 Aug 07
TA  - The Journal of Neuroscience
PG  - 13138--13149
VI  - 33
IP  - 32
4099  - http://www.jneurosci.org/content/33/32/13138.short
4100  - http://www.jneurosci.org/content/33/32/13138.full
SO  - J. Neurosci.2013 Aug 07; 33
AB  - Alzheimer's disease (AD) chiefly characterizes a progressively neurodegenerative disorder of the brain, and eventually leads to irreversible loss of intellectual abilities. The β-amyloid (Aβ)-induced neurodegeneration is believed to be the main pathological mechanism of AD, and Aβ production inhibition or its clearance promotion is one of the promising therapeutic strategies for anti-AD research. Here, we report that the natural product arctigenin from Arctium lappa (L.) can both inhibit Aβ production by suppressing β-site amyloid precursor protein cleavage enzyme 1 expression and promote Aβ clearance by enhancing autophagy through AKT/mTOR signaling inhibition and AMPK/Raptor pathway activation as investigated in cells and APP/PS1 transgenic AD model mice. Moreover, the results showing that treatment of arctigenin in mice highly decreased Aβ formation and senile plaques and efficiently ameliorated AD mouse memory impairment strongly highlight the potential of arctigenin in anti-AD drug discovery.