PT  - JOURNAL ARTICLE
AU  - Walid Jalabi
AU  - Cornelia Kopp-Scheinpflug
AU  - Paul D. Allen
AU  - Emanuele Schiavon
AU  - Rita R. DiGiacomo
AU  - Ian D. Forsythe
AU  - Stephen M. Maricich
TI  - Sound Localization Ability and Glycinergic Innervation of the Superior Olivary Complex Persist after Genetic Deletion of the Medial Nucleus of the Trapezoid Body
AID  - 10.1523/JNEUROSCI.2604-13.2013
DP  - 2013 Sep 18
TA  - The Journal of Neuroscience
PG  - 15044--15049
VI  - 33
IP  - 38
4099  - http://www.jneurosci.org/content/33/38/15044.short
4100  - http://www.jneurosci.org/content/33/38/15044.full
SO  - J. Neurosci.2013 Sep 18; 33
AB  - The medial nucleus of the trapezoid body (MNTB) in the superior olivary complex (SOC) is an inhibitory hub considered critical for binaural sound localization. We show that genetic ablation of MNTB neurons in mice only subtly affects this ability by prolonging the minimum time required to detect shifts in sound location. Furthermore, glycinergic innervation of the SOC is maintained without an MNTB, consistent with the existence of parallel inhibitory inputs. These findings redefine the role of MNTB in sound localization and suggest that the inhibitory network is more complex than previously thought.