RT Journal Article
SR Electronic
T1 Preparing for Selective Inhibition within Frontostriatal Loops
JF The Journal of Neuroscience
JO J. Neurosci.
FD Society for Neuroscience
SP 18087
OP 18097
DO 10.1523/JNEUROSCI.2167-13.2013
VO 33
IS 46
A1 Peter Smittenaar
A1 Marc Guitart-Masip
A1 Antoine Lutti
A1 Raymond J. Dolan
YR 2013
UL http://www.jneurosci.org/content/33/46/18087.abstract
AB Action inhibition can globally prevent all motor output or selectively cancel specific actions during concurrent motor output. Here we examine the behavioral and neural basis of selective inhibition focusing on the role of preparation. In 18 healthy human participants we manipulated the extent to which they could prepare for selective inhibition by providing or withholding information on what actions might need to be stopped. We show that, on average, information improves both speed and selectivity of inhibition. Functional magnetic resonance imaging data show that preparation for selective inhibition engages the inferior frontal gyrus, supplementary motor area, and striatum. Examining interindividual differences, we find the benefit of proactive control to speed and selectivity of inhibition trade off against each other, such that an improvement in stopping speed leads to a deterioration of selectivity of inhibition, and vice versa. This trade-off is implemented through engagement of the dorsolateral prefrontal cortex and putamen. Our results suggest proactive selective inhibition is implemented within frontostriatal structures, and we provide evidence that a speed-selectivity trade-off might underlie a range of findings reported previously.