PT  - JOURNAL ARTICLE
AU  - Aleksandra Janusz
AU  - Jacek Miłek
AU  - Małgorzata Perycz
AU  - Laura Pacini
AU  - Claudia Bagni
AU  - Leszek Kaczmarek
AU  - Magdalena Dziembowska
TI  - The Fragile X Mental Retardation Protein Regulates Matrix Metalloproteinase 9 mRNA at Synapses
AID  - 10.1523/JNEUROSCI.2207-13.2013
DP  - 2013 Nov 13
TA  - The Journal of Neuroscience
PG  - 18234--18241
VI  - 33
IP  - 46
4099  - http://www.jneurosci.org/content/33/46/18234.short
4100  - http://www.jneurosci.org/content/33/46/18234.full
SO  - J. Neurosci.2013 Nov 13; 33
AB  - Activity-dependent protein synthesis at synapses is dysregulated in the Fragile X syndrome (FXS). This process contributes to dendritic spine dysmorphogenesis and synaptic dysfunction in FXS. Matrix Metalloproteinase 9 (MMP-9) is an enzyme involved in activity-dependent reorganization of dendritic spine architecture and was shown to regulate spine morphology in a mouse model of FXS, the Fmr1 knock-out mice. Here we show that MMP-9 mRNA is part of the FMRP complex and colocalizes in dendrites. In the absence of FMRP MMP-9 mRNA translation is increased at synapses, suggesting that this mechanism contributes to the increased metalloproteinase level at synapses of Fmr1 knock-out mice. We propose that such a local effect can contribute to the aberrant dendritic spine morphology observed in the Fmr1 knock-out mice and in patients with FXS.