RT Journal Article SR Electronic T1 A Novel Function for Foxm1 in Interkinetic Nuclear Migration in the Developing Telencephalon and Anxiety-Related Behavior JF The Journal of Neuroscience JO J. Neurosci. FD Society for Neuroscience SP 1510 OP 1522 DO 10.1523/JNEUROSCI.2549-13.2014 VO 34 IS 4 A1 Xiaojing Wu A1 Xiaochun Gu A1 Xiaoning Han A1 Ailing Du A1 Yan Jiang A1 Xiaoyun Zhang A1 Yanjie Wang A1 Guangliang Cao A1 Chunjie Zhao YR 2014 UL http://www.jneurosci.org/content/34/4/1510.abstract AB Interkinetic nuclear migration (INM) is a key feature of cortical neurogenesis. INM functions to maximize the output of the neuroepithelium, and more importantly, balance the self-renewal and differentiation of the progenitors. Although INM has been reported to be highly correlated with the cell cycle, little is known about the effects of cell cycle regulators on INM. In this study, by crossing Foxm1fl/fl mice with Emx1-Cre line, we report that a conditional disruption of forkhead transcription factor M1 (Foxm1) in dorsal telencephalon results in abnormal cell cycle progression, leading to impaired INM through the downregulation of Cyclin b1 and Cdc25b. The impairment of INM disturbs the synchronization of apical progenitors (APs) and promotes the transition from APs to basal progenitors (BPs) in a cell-autonomous fashion. Moreover, ablation of Foxm1 causes anxiety-related behaviors in adulthood. Thus, this study provides evidence of linkages among the cell cycle regulator Foxm1, INM, and adult behavior.