PT  - JOURNAL ARTICLE
AU  - Jeremy Viczko
AU  - Arjun V. Sharma
AU  - Silvia Pagliardini
AU  - Trish Wolansky
AU  - Clayton T. Dickson
TI  - Lack of Respiratory Coupling with Neocortical and Hippocampal Slow Oscillations
AID  - 10.1523/JNEUROSCI.3581-13.2014
DP  - 2014 Mar 12
TA  - The Journal of Neuroscience
PG  - 3937--3946
VI  - 34
IP  - 11
4099  - http://www.jneurosci.org/content/34/11/3937.short
4100  - http://www.jneurosci.org/content/34/11/3937.full
SO  - J. Neurosci.2014 Mar 12; 34
AB  - Previous work has demonstrated an influence of the respiratory cycle and, more specifically, rhythmic nasal inspiration for the entrainment of slow oscillations in olfactory cortex during ketamine-xylazine anesthesia. This respiratory entrainment has been suggested to occur more broadly during slow-wave states (including sleep) throughout the forebrain, in particular in the frontal and parahippocampal and hippocampal cortices. Using multisite local field potential recording methods and spectral coherence analysis in the rat, we show here that no such broad forebrain coupling takes place during slow-wave activity patterns under either ketamine-xylazine or urethane anesthesia and, furthermore, that it also does not arise during natural slow-wave sleep. Therefore, respiratory-related oscillatory neural activities are likely limited to primary olfactory structures during slow-wave forebrain states.