RT Journal Article
SR Electronic
T1 Loss of hnRNP K Impairs Synaptic Plasticity in Hippocampal Neurons
JF The Journal of Neuroscience
JO J. Neurosci.
FD Society for Neuroscience
SP 9088
OP 9095
DO 10.1523/JNEUROSCI.0303-14.2014
VO 34
IS 27
A1 Alessandra Folci
A1 Lisa Mapelli
A1 Jenny Sassone
A1 Francesca Prestori
A1 Egidio D'Angelo
A1 Silvia Bassani
A1 Maria Passafaro
YR 2014
UL http://www.jneurosci.org/content/34/27/9088.abstract
AB Heterogeneous nuclear ribonucleoprotein K (hnRNP K) is an RNA-binding protein implicated in RNA metabolism. Here, we investigated the role of hnRNP K in synapse function. We demonstrated that hnRNP K regulates dendritic spine density and long-term potentiation (LTP) in cultured hippocampal neurons from embryonic rats. LTP requires the extracellular signal-regulated kinase (ERK)1/2-mediated phosphorylation and cytoplasmic accumulation of hnRNP K. Moreover, hnRNP K knockdown prevents ERK cascade activation and GluA1-S845 phosphorylation and surface delivery, which are essential steps for LTP. These findings establish hnRNP K as a new critical regulator of synaptic transmission and plasticity in hippocampal neurons.