%0 Journal Article
%A Simon Weiler
%A Stefanie Krinner
%A Aaron B. Wong
%A Tobias Moser
%A Tina Pangršič
%T ATP Hydrolysis Is Critically Required for Function of CaV1.3 Channels in Cochlear Inner Hair Cells via Fueling Ca2+ Clearance
%D 2014
%R 10.1523/JNEUROSCI.4990-13.2014
%J The Journal of Neuroscience
%P 6843-6848
%V 34
%N 20
%X Sound encoding is mediated by Ca2+ influx-evoked release of glutamate at the ribbon synapse of inner hair cells. Here we studied the role of ATP in this process focusing on Ca2+ current through CaV1.3 channels and Ca2+ homeostasis in mouse inner hair cells. Patch-clamp recordings and Ca2+ imaging demonstrate that hydrolyzable ATP is essential to maintain synaptic Ca2+ influx in inner hair cells via fueling Ca2+-ATPases to avoid an increase in cytosolic [Ca2+] and subsequent Ca2+/calmodulin-dependent inactivation of CaV1.3 channels.
%U https://www.jneurosci.org/content/jneuro/34/20/6843.full.pdf