%0 Journal Article %A Simon Weiler %A Stefanie Krinner %A Aaron B. Wong %A Tobias Moser %A Tina Pangršič %T ATP Hydrolysis Is Critically Required for Function of CaV1.3 Channels in Cochlear Inner Hair Cells via Fueling Ca2+ Clearance %D 2014 %R 10.1523/JNEUROSCI.4990-13.2014 %J The Journal of Neuroscience %P 6843-6848 %V 34 %N 20 %X Sound encoding is mediated by Ca2+ influx-evoked release of glutamate at the ribbon synapse of inner hair cells. Here we studied the role of ATP in this process focusing on Ca2+ current through CaV1.3 channels and Ca2+ homeostasis in mouse inner hair cells. Patch-clamp recordings and Ca2+ imaging demonstrate that hydrolyzable ATP is essential to maintain synaptic Ca2+ influx in inner hair cells via fueling Ca2+-ATPases to avoid an increase in cytosolic [Ca2+] and subsequent Ca2+/calmodulin-dependent inactivation of CaV1.3 channels. %U https://www.jneurosci.org/content/jneuro/34/20/6843.full.pdf