TY - JOUR T1 - Tau Phosphorylation at Serine 396 Residue Is Required for Hippocampal LTD JF - The Journal of Neuroscience JO - J. Neurosci. SP - 4804 LP - 4812 DO - 10.1523/JNEUROSCI.2842-14.2015 VL - 35 IS - 12 AU - Philip Regan AU - Thomas Piers AU - Jee-Hyun Yi AU - Dong-Hyun Kim AU - Seonghoo Huh AU - Se Jin Park AU - Jong Hoon Ryu AU - Daniel J. Whitcomb AU - Kwangwook Cho Y1 - 2015/03/25 UR - http://www.jneurosci.org/content/35/12/4804.abstract N2 - Tau is required for the induction of long-term depression (LTD) of synaptic transmission in the hippocampus. Here we probe the role of tau in LTD, finding that an AMPA receptor internalization mechanism is impaired in tau KO mice, and that LTD causes specific phosphorylation at the serine 396 and 404 residues of tau. Surprisingly, we find that phosphorylation at serine 396, specifically, is critical for LTD but has no role in LTP. Finally, we show that tau KO mice exhibit deficits in spatial reversal learning. These findings underscore the physiological role for tau at the synapse and identify a behavioral correlate of its role in LTD. ER -