RT Journal Article SR Electronic T1 Network Structure Shapes Spontaneous Functional Connectivity Dynamics JF The Journal of Neuroscience JO J. Neurosci. FD Society for Neuroscience SP 5579 OP 5588 DO 10.1523/JNEUROSCI.4903-14.2015 VO 35 IS 14 A1 Kelly Shen A1 R. Matthew Hutchison A1 Gleb Bezgin A1 Stefan Everling A1 Anthony R. McIntosh YR 2015 UL http://www.jneurosci.org/content/35/14/5579.abstract AB The structural organization of the brain constrains the range of interactions between different regions and shapes ongoing information processing. Therefore, it is expected that large-scale dynamic functional connectivity (FC) patterns, a surrogate measure of coordination between brain regions, will be closely tied to the fiber pathways that form the underlying structural network. Here, we empirically examined the influence of network structure on FC dynamics by comparing resting-state FC (rsFC) obtained using BOLD-fMRI in macaques (Macaca fascicularis) to structural connectivity derived from macaque axonal tract tracing studies. Consistent with predictions from simulation studies, the correspondence between rsFC and structural connectivity increased as the sample duration increased. Regions with reciprocal structural connections showed the most stable rsFC across time. The data suggest that the transient nature of FC is in part dependent on direct underlying structural connections, but also that dynamic coordination can occur via polysynaptic pathways. Temporal stability was found to be dependent on structural topology, with functional connections within the rich-club core exhibiting the greatest stability over time. We discuss these findings in light of highly variable functional hubs. The results further elucidate how large-scale dynamic functional coordination exists within a fixed structural architecture.