RT Journal Article
SR Electronic
T1 Circuit and Synaptic Plasticity Mechanisms of Drug Relapse
JF The Journal of Neuroscience
JO J. Neurosci.
FD Society for Neuroscience
SP 10867
OP 10876
DO 10.1523/JNEUROSCI.1821-17.2017
VO 37
IS 45
A1 Yan Dong
A1 Jane R. Taylor
A1 Marina E. Wolf
A1 Yavin Shaham
YR 2017
UL http://www.jneurosci.org/content/37/45/10867.abstract
AB High rates of relapse to drug use during abstinence is a defining feature of human drug addiction. This clinical scenario has been studied at the preclinical level using different animal models in which relapse to drug seeking is assessed after cessation of operant drug self-administration in rodents and monkeys. In our Society for Neuroscience (SFN) session entitled “Circuit and Synaptic Plasticity Mechanisms of Drug Relapse,” we will discuss new developments of our understanding of circuits and synaptic plasticity mechanisms of drug relapse from studies combining established and novel animal models with state-of-the-art cellular, electrophysiology, anatomical, chemogenetic, and optogenetic methods. We will also discuss the translational implications of these new developments. In the mini-review that introduces our SFN session, we summarize results from our laboratories on behavioral, cellular, and circuit mechanisms of drug relapse within the context of our session.