PT  - JOURNAL ARTICLE
AU  - Sean Froudist-Walsh
AU  - Philip G.F. Browning
AU  - Paula L. Croxson
AU  - Kathy L. Murphy
AU  - Jul Lea Shamy
AU  - Tess L. Veuthey
AU  - Charles R.E. Wilson
AU  - Mark G. Baxter
TI  - The Rhesus Monkey Hippocampus Critically Contributes to Scene Memory Retrieval, But Not New Learning
AID  - 10.1523/JNEUROSCI.0832-18.2018
DP  - 2018 Sep 05
TA  - The Journal of Neuroscience
PG  - 7800--7808
VI  - 38
IP  - 36
4099  - http://www.jneurosci.org/content/38/36/7800.short
4100  - http://www.jneurosci.org/content/38/36/7800.full
SO  - J. Neurosci.2018 Sep 05; 38
AB  - Humans can recall a large number of memories years after the initial events. Patients with amnesia often have lesions to the hippocampus, but human lesions are imprecise, making it difficult to identify the anatomy underlying memory impairments. Rodent studies enable great precision in hippocampal manipulations, but not investigation of many interleaved memories. Thus it is not known how lesions restricted to the hippocampus affect the retrieval of multiple sequentially encoded memories. Furthermore, disagreement exists as to whether hippocampal inactivations lead to temporally graded or ungraded amnesia, which could be a consequence of differences between rodent and human studies. In the current study, rhesus monkeys of both sexes received either bilateral neurotoxic hippocampal lesions or remained unoperated controls and were tested on recognition and new learning of visual object-in-place scenes. Monkeys with hippocampal lesions were significantly impaired at remembering scenes that were encoded before the lesion. We did not observe any temporal gradient effect of the lesion on memory recognition, with recent and remote memories being equally affected by the lesion. Monkeys with hippocampal lesions showed no deficits in learning new scenes. Thus, the hippocampus, like other cortical regions, may be engaged in the acquisition and storage of new memories, but the role of the damaged hippocampus can be taken over by spared hippocampal tissue or extra-hippocampal regions following a lesion. These findings illustrate the utility of experimental paradigms for studying retrograde and anterograde amnesia that make use of the capacity of nonhuman primates to rapidly acquire many distinct visual memories.SIGNIFICANCE STATEMENT Recalling old memories, creating new memories, and the process by which memories transition from temporary to permanent storage all may rely on the hippocampus. Whether the hippocampus is necessary for encoding and retrieval of multiple related visual memories in primates is not known. Monkeys that learned many visual memory problems before precise lesions of the hippocampus were impaired at recalling those memories after hippocampal damage regardless of when the memories were formed, but could learn new memory problems at a normal rate. This suggests the hippocampus is normally vital for retrieval of complex visual memories regardless of their age, and also points to the importance of investigating mechanisms by which memories may be acquired in the presence of hippocampal damage.