Table 2.

Thirteen genes regulated in common at 24 h after stroke in mice preconditioned with LPS, CpG, or brief ischemia

SymbolTitleLPS + stroke 24 hCpG + stroke 24 hIP + stroke 24 hStrokea 24 h
Fold changebFDR-adjusted p valueFold changeFDR-adjusted p valueFold changeFDR-adjusted p valueFold changeFDR-adjusted p value
Fcgr1Fc receptor, IgG, high affinity I3.062.8 × 10−93.032.3 × 10−92.361.3 × 10−51.85/1.770.0004/0.001
HGFHepatocyte growth factor2.562.1 × 10−93.046.1 × 10−122.306.0 × 10−71.49/1.850.007/3.2 × 10−5
Ifit1IFN-induced protein with tetratricopeptide repeats 13.040.00012.610.00092.850.0011.39/1.280.32/0.45
Ifit3IFN-induced protein with tetratricopeptide repeats 32.072.1 × 10−52.042.4 × 10−52.040.00011.54/1.400.01/0.05
Oasl22′-5′Oligoadenylate synthetase-like 22.470.00092.590.00042.550.0021.24/1.190.51/0.58
Plscr2Phospholipid scramblase 22.563.9 × 10−72.939.4 × 10−92.110.00011.32/1.450.15/0.04
PycardPYD and CARD domain containing2.608.9 × 10−92.578.3 × 10−92.273.6 × 10−61.69/1.680.0007/0.0009
Pyhin1Pyrin and HIN domain family, 12.663.9 × 10−62.529.4 × 10−62.170.00081.44/1.850.09/0.003
ViperinRadical S-adenosyl methionine domain containing 23.824.2 × 10−63.020.00012.670.0021.84/1.750.03/0.05
Rtp4Receptor transporter protein 42.961.3 × 10−72.661.0 × 10−62.483.9 × 10−51.56/1.520.02/0.03
Trim30Tripartite motif protein 302.502.5 × 10−62.433.9 × 10−62.090.00051.50/1.530.03/0.02
Usp18Ubiquitin specific peptidase 182.930.00012.680.00033.408.7 × 10−51.35/1.160.34/0.6
Zbp1Z-DNA binding protein 12.201.0 × 10−52.792.0 × 10−82.070.00021.57/1.660.01/0.003

  • ↵aNontreated stroke alone/saline-treated stroke.

  • ↵bFold change compared with untreated mice. Genes are considered significantly regulated if fold change > 2 and FDR-adjusted p < 0.01.