[3H]DTBZ binding in rat brain: influence of chronic unlimited access to self-administration of cocaine
| Brain region | Control | On-cocaine | Withdrawn |
|---|---|---|---|
| Cortex | |||
| Frontal | 12.7 ± 0.2 | 9.0 ± 0.7 | 8.1 ± 1.1 |
| Cingulate | 12.2 ± 0.7 | 13.5 ± 1.1 | 12.5 ± 1.3 |
| Limbic | 20.4 ± 0.9 | 21.7 ± 1.6 | 18.7 ± 2.0 |
| Occipital | 5.2 ± 0.2 | 5.3 ± 0.8 | 3.9 ± 0.8 |
| Basal ganglia | |||
| Nucleus accumbens | |||
| Whole | 240 ± 5 | 231 ± 10 | 224 ± 10 |
| Anterior | 254 ± 6 | 234 ± 8 | 233 ± 12 |
| Posterior | 224 ± 3 | 226 ± 14 | 218 ± 9 |
| Striatum | |||
| Whole | 202 ± 2 | 198 ± 9 | 191 ± 10 |
| Rostral pole | 257 ± 10 | 227 ± 16 | 229 ± 12 |
| Dorsomedial | 266 ± 15 | 228 ± 26 | 235 ± 19 |
| Dorsolateral | 248 ± 9 | 213 ± 14 | 235 ± 14 |
| Ventromedial | 273 ± 10 | 260 ± 11 | 241 ± 16 |
| Ventrolateral | 225 ± 11 | 206 ± 13 | 201 ± 12 |
| Rostral body | 238 ± 5 | 233 ± 14 | 231 ± 10 |
| Dorsomedial | 248 ± 9 | 250 ± 18 | 249 ± 10 |
| Dorsointermed. | 232 ± 6 | 241 ± 15 | 227 ± 11 |
| Dorsolateral | 229 ± 8 | 223 ± 11 | 220 ± 8 |
| Intermed.-medial | 265 ± 8 | 254 ± 16 | 262 ± 12 |
| Intermed.-intermed. | 215 ± 6 | 210 ± 12 | 203 ± 11 |
| Intermed.-lateral | 209 ± 7 | 203 ± 10 | 198 ± 12 |
| Ventromedial | 266 ± 7 | 251 ± 16 | 258 ± 12 |
| Ventrointermed. | 245 ± 6 | 239 ± 16 | 236 ± 11 |
| Ventrolateral | 238 ± 5 | 228 ± 15 | 226 ± 13 |
| Intermediate body | 199 ± 4 | 209 ± 12 | 194 ± 12 |
| Dorsomedial | 202 ± 8 | 230 ± 16 | 211 ± 14 |
| Dorsointermed. | 188 ± 6 | 199 ± 15 | 182 ± 13 |
| Dorsolateral | 212 ± 9 | 212 ± 9 | 194 ± 15 |
| Intermed.-medial | 174 ± 6 | 186 ± 16 | 175 ± 14 |
| Intermed.-intermed. | 169 ± 3 | 173 ± 11 | 158 ± 10 |
| Intermed.-lateral | 212 ± 7 | 212 ± 6 | 187 ± 10 |
| Ventromedial | 169 ± 7 | 164 ± 11 | 163 ± 10 |
| Ventrointermed. | 218 ± 6 | 221 ± 10 | 209 ± 11 |
| Ventrolateral | 256 ± 7 | 257 ± 9 | 233 ± 15 |
| Caudal body | 179 ± 3 | 174 ± 6 | 168 ± 10 |
| Dorsal | 129 ± 5 | 132 ± 7 | 130 ± 10 |
| Intermed. | 170 ± 4 | 162 ± 6 | 156 ± 11 |
| Ventral | 248 ± 7 | 235 ± 9 | 227 ± 13 |
| Caudate tail | 112 ± 5 | 109 ± 8 | 97 ± 7 |
| Bed nucleus of stria terminalis | |||
| Anterior | 89 ± 5 | 80 ± 6 | 93 ± 7 |
| Ventral | 148 ± 9 | 145 ± 10 | 130 ± 11 |
| Fundus striati | 221 ± 6 | 187 ± 24 | 195 ± 19 |
| Globus pallidus | 11.7 ± 0.8 | 11.8 ± 1.0 | 9.8 ± 1.6 |
| Basal forebrain | |||
| Olfactory tubercle | |||
| Whole | 192 ± 5 | 182 ± 5 | 185 ± 5 |
| Anterior | 192 ± 6 | 183 ± 4 | 185 ± 6 |
| Posterior | 188 ± 7 | 181 ± 8 | 182 ± 4 |
| Lateral septum | |||
| Dorsal | 208 ± 7 | 256 ± 19 | 239 ± 9 |
| Intermed. | 58 ± 3 | 78 ± 10 | 69 ± 6 |
| Ventral | 172 ± 6 | 196 ± 19 | 191 ± 13 |
| Medial septum | 47 ± 5 | 49 ± 6 | 45 ± 8 |
| Pyramidal cell layer | 22 ± 1 | 25 ± 2 | 22 ± 3 |
| Hippocampus | 12 ± 1 | 14 ± 1 | 12 ± 1 |
| Basolateral amygdala | 51 ± 2 | 54 ± 3 | 48 ± 3 |
| Diencephalon | |||
| Suprachiasmatic nucleus | 89 ± 14 | 80 ± 9 | 57 ± 14 |
| Supraoptic nucleus | 145 ± 9 | 151 ± 10 | 167 ± 11 |
| Paraventricular nucleus | 150 ± 8 | 183 ± 14 | 160 ± 13 |
| Hypothalamus | |||
| Anterior | 61 ± 3 | 76 ± 4 | 62 ± 4 |
| Dorsomedial | 79 ± 7 | 83 ± 5 | 79 ± 8 |
| Ventromedial | 57 ± 3 | 56 ± 4 | 58 ± 3 |
| Lateral preoptic area | 51 ± 3 | 54 ± 6 | 53 ± 5 |
| Medial preoptic area | 80 ± 3 | 88 ± 3 | 77 ± 6 |
| Habenula | |||
| Medial | 28 ± 2 | 31 ± 4 | 30 ± 3 |
| Lateral | 16 ± 5 | 11 ± 2 | 15 ± 4 |
| Thalamus | |||
| Anteroventral thalamic nucleus | 55 ± 3 | 51 ± 3 | 54 ± 5 |
| Paratenial thalamic nucleus | 74 ± 9 | 72 ± 11 | 75 ± 7 |
| Paraventricular thalamic nucleus | 88 ± 6 | 87 ± 7 | 100 ± 12 |
| Midbrain | |||
| Substantia nigra | 92 ± 8 | 82 ± 5 | 81 ± 7 |
| Ventral tegmental area | 101 ± 5 | 94 ± 6 | 91 ± 8 |
| Superior colliculus | 27 ± 1 | 29 ± 2 | 25 ± 2 |
| Periaqueductal grey | 33 ± 2 | 37 ± 3 | 34 ± 4 |
| Medial raphe | 56 ± 14 | 43 ± 12 | 61 ± 13 |
| Dorsal raphe | 144 ± 12 | 148 ± 11 | 140 ± 21 |
| Subincertal nucleus | 55 ± 3 | 51 ± 4 | 44 ± 3 |
| Brainstem | |||
| Locus coeruleus | 174 ± 39 | 267 ± 23 | 209 ± 47 |
Data are subregional distribution (mean ± SEM; pmol/μg tissue) of [3H]DTBZ binding in brain of control rats (n = 15) and of rats killed on the last day of (n = 10) or 3 weeks after withdrawal from (n = 8) chronic, unlimited access to self-administration of cocaine.