Rise-time criteria and LTP
| Rise time limit (msec) | Control | Naloxone | ||
|---|---|---|---|---|
| Mean rise time | LTP % | Mean rise time | LTP % | |
| <2.5 | 1.5 ± 0.1 | 52 ± 11 | 1.6 ± 0.2 | −3 ± 12 |
| (n) | 17 | 14 of 17 | 13 | 4 of 13 |
| <2.0 | 1.2 ± 0.1 | 54 ± 15 | 1.2 ± 0.2 | −9 ± 18 |
| (n) | 14 | 12 of 14 | 8 | 3 of 8 |
| <1.5 | 1.0 ± 0.1 | 40 ± 16 | 1.0 ± 0.10 | −17 ± 23 |
| (n) | 9 | 7 of 9 | 6 | 2 of 6 |
| <1.0 | 0.8 ± 0.1 | 62 ± 30 | 0.7 | −20 |
| (n) | 4 | 4 of 4 | 2 | 1 of 2 |
This table illustrates the effect of increasingly stringent rise-time criteria on the control and naloxone data groups. The left column indicates the 10–90% rise-time limit (e.g., the bottom row shows cells with a rise time of <1.0 msec). Mean rise-time values are for all the cells that pass the particular rise-time criteria, and LTP percentage is the mean increase in EPSP amplitude. Note that data subsets with very stringent rise-time criteria still support the conclusion that naloxone blocks mossy fiber LTP induction.