Table 2.

Proteins unchanged by ERK1 antisense oligonucleotide intra-VTA infusions

% of sham
GFAP102  ± 12
NF 6892  ± 11
NF 160112  ± 9
NF 200106  ± 8
PI3-K94  ± 11
PLC-γ103  ± 8
JAK2110  ± 12
  • Lack of effect of ERK1 antisense oligonucleotide infusions (10 μg/d) on cellular signaling proteins. Proteins analyzed include glial fibrillary acidic protein (GFAP); neurofilament proteins (NF 68, 160, and 200); phosphatidylinositol 3-kinase (PI3-K); phospholipase C-γ (PLC-γ); and Janus kinase-2 (JAK2).