Mean (±SEM) of % of time on open arms, and number of closed arm entries made on trial 1 on the elevated plus-maze
| Median raphé | n | % time on open arms | Number of closed arm entries |
|---|---|---|---|
| Vehicle | 9 | 22.8 ± 1.5 | 10.7 ± 1.1 |
| 8-OH-DPAT | |||
| 100 ng | 9 | 43.0* ± 8.4 | 10.0 ± 0.9 |
| 200 ng | 10 | 47.4** ± 4.7 | 8.4 ± 1.2 |
Rats were tested 3 min after administration of vehicle (aCSF), 8-OH-DPAT (50, 100, and 200 ng), or (±)tertatolol (3 μg) to the median raphé nucleus or bilaterally to the dorsal hippocampus.
* p < 0.05; **p < 0.01 compared with vehicle.