Counts of TH+ neuronal profiles in the NPG from postnatal day 1 mice with different combinations of functional and disrupted BDNF, NT4, and TrkB alleles
| Genotype (bdnf/nt4/trkb) | TH+ profile number (n) | Change (%) | |
|---|---|---|---|
| A | (+/+)/(+/+)/(+/+) | 393 ± 18 (6) | 0 |
| B | (+/−)/(+/+)/(+/+) | 266 ± 17 (6)a,b | −32 |
| C | (−/−)/(+/+)/(+/+) | 165 ± 11 (6)2_a | −58 |
| D | (+/+)/(+/−)/(+/+) | 448 ± 22 (6)e,g | +14 |
| E | (+/+)/(−/−)/(+/+) | 353 ± 40 (5)2_e | −10 |
| F | (−/−)/(+/−)/(+/+) | 169 ± 32 (3)f,d | −57 |
| G | (+/−)/(−/−)/(+/+) | 247 ± 10 (8)c,d | −37 |
| H | (−/−)/(−/−)/(+/+) | 66 ± 2 (4)b,c | −83 |
| I | (+/+)/(+/+)/(−/−) | 53 ± 8 (3)2_h | −86 |
Profile counts are shown as means ± SE. Percent change is compared with wild-type (bdnf+/+nt4+/+trkb+/+).
↵F2_a Differs frombdnf+/+nt4+/+trkb+/+(wild-type).
F2_b Differs frombdnf−/−nt4+/+trkb+/+(BDNF knockout).
F2_c Differs frombdnf+/+nt4−/−trkb+/+(NT4 knockout).
F2_d Differs frombdnf−/−nt4−/−trkb+/+(BDNF/NT4 double knockout).
↵F2_e Not different frombdnf+/+nt4+/+trkb+/+(wild-type).
F2_f Not different frombdnf−/−nt4+/+trkb+/+(BDNF knockout).
F2_g Not different frombdnf+/+nt4−/−trkb+/+(NT4 knockout).
↵F2_h Not different frombdnf−/−nt4−/−trkb+/+(BDNF/NT4 double knockout); comparison using Student’s ttest, α = 0.05.