Effect of NMDA antagonists on mean relative cell volume at peak veratridine-induced swelling and after long-term veratridine exposure
| Experiment | Relative cell volume 15–20 min after veratridine exposure | Relative cell volume 85–90 min after veratridine exposure | Neurons undergoing RVD (%) |
|---|---|---|---|
| 100 μm 7-CK | 1.78 ± 0.03 | 1.15 ± 0.06 | 100 |
| (n = 5;5) | p < 0.0001 | ||
| 5 mm AP-5 | 1.84 ± 0.18 | 1.25 ± 0.11 | 100 |
| (n = 4;5) | p < 0.03 | ||
| 100 μm CNQX (no added glycine) | 1.65 ± 0.14 | 0.95 ± 0.09 | 100 |
| (n = 5;5) | p < 0.006 |
Cultures were preincubated with NMDA antagonists for 5 min before the addition of 100 μm veratridine to the bath. Values are mean ± SE.