Effect of acute Δ9-THC treatment on basal and WIN 55212-2-stimulated [35S]GTPγS binding in the rat brain
| Region | Basal | Stimulated | ||
|---|---|---|---|---|
| Control | Acute Δ9-THC | Control | Acute Δ9-THC | |
| Hippocampus (D) | 100 ± 4% | 92 ± 2% | 161 ± 12% | 140 ± 6% |
| Hippocampus (M) | 100 ± 5% | 116 ± 5% | 172 ± 24% | 176 ± 5% |
| Hippocampus (V) | 100 ± 14% | 123 ± 2% | 183 ± 13% | 194 ± 8% |
| Perirhinal cortex (M) | 100 ± 5% | 112 ± 6% | 161 ± 17% | 166 ± 8% |
| Perirhinal cortex (V) | 100 ± 1% | 101 ± 3% | 145 ± 5% | 147 ± 8% |
| Entorhinal cortex (D) | 100 ± 6% | 97 ± 1% | 155 ± 10% | 148 ± 4% |
| Entorhinal cortex (M) | 100 ± 7% | 120 ± 6% | 170 ± 12% | 176 ± 6% |
| Entorhinal cortex (V) | 100 ± 16% | 112 ± 4% | 157 ± 10% | 164 ± 7% |
| Septum | 100 ± 7% | 97 ± 10% | 141 ± 6% | 127 ± 5% |
| Caudate-putamen (D) | 100 ± 10% | 100 ± 3% | 190 ± 19% | 181 ± 2% |
| Caudate-putamen (M) | 100 ± 10% | 112 ± 2% | 183 ± 11% | 201 ± 4% |
| Globus pallidus | 100 ± 7% | 109 ± 6% | 382 ± 23% | 379 ± 10% |
| Substantia nigra | 100 ± 8% | 116 ± 1% | 393 ± 21% | 437 ± 12% |
| Cerebellum | 100 ± 6% | 115 ± 5% | 194 ± 21% | 189 ± 6% |
| PAG | 100 ± 6% | 102 ± 7% | 122 ± 6% | 124 ± 5% |
Sections were incubated with 2 mm GDP, and then with [35S]GTPγS (0.04 nm) and 2 mmGDP, in the presence and absence of 10 μm WIN 55212-2. Data are expressed as percentage of control basal binding and represent mean values ± SE of duplicate sections from three animals. The level of the sections measured are dorsal (D), midlevel (M), and ventral (V).