Density of α7 mRNA and [125I]α-BTX binding-site expression in the primary barrel region of P5 pups that received an electrolytic VB lesion at P0
| Cortical hemisphere | α7 mRNA (dpm/mg) | [125I]α-BTX (fmol/mg) | ||
|---|---|---|---|---|
| IV | VI | IV | VI | |
| Control | 321.86 ± 26.53 | 728.28 ± 61.33 | 0.94 ± 0.05 | 1.54 ± 0.15 |
| Lesioned | 112.54 ± 16.39‡ | 153.83 ± 33.21‡ | 0.17 ± 0.08‡ | 0.29 ± 0.17‡ |
mRNA and binding-site density were determined at the level of layers IV and VI of control and lesioned cortical hemispheres. Animals were unilaterally lesioned on P0 as described in Materials and Methods and allowed to survive for 5 d postlesion. Data represent the mean ± SEM for five animals. ‡, p < 0.001 significantly different from the control hemisphere.