30 mg/kg PTZ | 50 mg/kg PTZ | |||
---|---|---|---|---|
Wt | Jrk+/− | Wt | Jrk+/− | |
Number of animals displaying clonus | 4/10 (40%) | 8/13 (62%) | 11/12 (92%) | 11/12 (92%) |
Mean number of clonic events ±SEM/animal | 0.5 ± 0.2 | 3.9 ± 1.2 | 1.5 ± 0.2 | 3.2 ± 1.1 |
Significance (median test) | <0.05 | NS | ||
Death | 0/10 (0%) | 1/13 (7.7%) | 1/12 (8.3%) | 8/12 (66.7%) |
Significance (Fisher’s exact test) | NS | <0.0075 | ||
Percent of time observed in clonus | 0.6 | 4.7 | 2.2 | 9.5 |
Significance (χ2) | <0.001 | <0.0001 |
NS, Not significant.