Table 1.

Analysis of LTP in CA1 in control and mGluR5 mutant mice using differential slope parameters

mGluR5 genotypeSlope measurement
5–95% of slope1-a5–95% of slope in AP51-a10–60% of slope
+/+ Genotype177.6  ± 10.2;  n = 19164.8  ± 16;  n = 8;168  ± 14;  n = 19;
p  = 0.411-bp  = 0.4951-b
−/− Genotype150.5  ± 5.7; n = 19149.9  ± 12; n = 8148  ± 11; n = 19
+/+ vs −/−p  = 0.016p  = 0.431p  = 0.244

  • ↵F1-a  AP5 (50 μm) was added 20 min after tetanic stimulation.

  • ↵F1-b  p values for a comparison with the first column, ++, 5–95% slope, four-train tetanic stimulation.n represents the number of slices. Each mouse yielded one or two slices.