Animals with behavioral seizure score ≥ grade 3 (%)3-b | Median seizure score3-c | ||||||
---|---|---|---|---|---|---|---|
No. of seizures3-a | n | First trial | Last trial | Retest | First trial | Last trial | Retest |
1 | 5 | 0.0 | xxx | 0.0 | 1 | 1 | 1 |
2 | 6 | 0.0 | 0.0 | 16.7 | 1 | 1 | 1.5 |
4 | 6 | 0.0 | 0.0 | 33.3 | 1 | 1 | 23-150 |
6 | 6 | 0.0 | 0.0 | 33.3 | 1 | 1 | 23-150 |
8 | 18 | 5.6 | 11.1 | 88.93-168 | 1 | 1 | 43-165 |
↵F3-a Mice were administered 10% flurothyl by inhalation until a sustained generalized seizure was expressed. A single or multiple generalized seizures (intertrial interval, 24 hr) were followed 28 d later by a retest trial when the behavioral seizure score was assigned.
↵F3-b Values are the percent of group total expressing a behavioral seizure score of grade 3 or higher. Asterisks indicate statistically significant differences between the retest trial and the last trial by the McNemar test:
↵F3-168 p < 0.001.
↵F3-c Values are the median seizure scores. Asterisks indicate statistically significant differences between the retest trial and the last trial by the Wilcoxon signed-ranks test;
↵F3-150 p < 0.05,
↵F3-165 p < 0.001.