Table 1.

Dose-dependent decreases in REM sleep and increases in non-REM sleep in the first hour after microinjection of 5-HT into the LDT nuclei in five rats

Intervention% REM% non-REM
1.5 mm 5-HT16.3  ± 3.9*81.1  ± 4.6*
1.0 mm 5-HT21.8  ± 2.473.8  ± 3.2
Saline27.7  ± 1.668.4  ± 2.2
Sham (i.e., no microinjection)26.7  ± 4.068.4  ± 3.8
One-way ANOVA-RMp = 0.037p = 0.025
  • Values are mean ± SEM.

  • * p < 0.025 compared with saline from post hoc paired t test.